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Chapter 5. Genetic and Environmental Factors that Influence Social Cognitive Skills in ASD

Chapter 5. Genetic and Environmental Factors that Influence Social Cognitive Skills in ASD

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Chapter 4. Speech, Language, and Communication Phenotypes in ASD

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SIDER, 2015. SIDER 4.1: Side Effect Resources

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Chapter 3. Evidence of Genetic and Epigenetic Risk Components of Autism and Autism Spectrum Disorder

Chapter 3. Evidence of Genetic and Epigenetic Risk Components of Autism and Autism Spectrum Disorder


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CHAPTER 2. Symptoms and Diagnosis of Autism

CHAPTER 2. Symptoms and Diagnosis of Autism

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Hara M et al. 2015. De novo SHANK3 mutation causes Rett syndrome-like phenotype in a female patient. Am J Med Genet A. 167(7):1593-6. doi: 10.1002/ajmg.a.36775.

Hippolyte L et al., 2016. The number of genomic copies at the 16p11.2 locus modulates language, verbal memory, and inhibition. Biol Psychiatry. 80(2):129-39. doi: 10.1016/j.biopsych.2015.10.021.

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Isles AR et al., 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genet. 12(5):e1005993. doi: 10.1371/journal.pgen.1005993.

Kanne SM and Mazurek MO. 2011. Aggression in children and adolescents with ASD: prevalence and risk factors. J Autism Dev Disord. 41(7):926-37. doi: 10.1007/s10803-010-1118-4.

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Le Couteur A, et al. 1996. A broader phenotype of autism: the clinical spectrum in twins. J Child Psychol Psychiatr Allied Disc 37:785–801

Loke YJ et al. 2015. The role of epigenetic change in autism spectrum disorders. Front Neurol. 6:107. doi: 10.3389/fneur.2015.00107.

Lopez-Hernandez, T. et al. 2011. Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly and macrocephaly with retardation and autism. Am J Hum Genet, 88(4): p. 422-32.

Li X et al. 2009. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 207(1-2):111-6. doi: 10.1016/j.jneuroim.2008.12.002.

Maezawa I et al., 2011. Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol. 7(1):85-97. doi: 10.1017/S1740925X1200004X.

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Molloy CA et al. 2006. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol. 172(1-2):198-205.

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Philippe A et al., 2015. Case report: an unexpected link between partial deletion of the SHANK3 gene and Heller’s dementia infantilis, a rare subtype of autism spectrum disorder. BMC Psychiatry. 15:256. doi: 10.1186/s12888-015-0631-6.

Pino-López M, Romero-Ayuso DM. 2013. [Parental occupational exposures and autism spectrum disorder in children]. Rev Esp Salud Publica. 87(1):73-85. doi: 10.4321/S1135-57272013000100008.

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Shenouda et al., 2015. Prevalence of Regressive Autism from 2000 to 2010: Findings from a Population-Based System. ISNAR Meeting, May 13-16.

Shetreat-Klein M 2014. Abnormalities of joint mobility and gait in children with autism spectrum disorders. Brain Dev. 36(2):91-6. doi: 10.1016/j.braindev.2012.02.005.

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Stoch YK et al., 2012. Are prenatal ultrasound scans associated with the autism phenotype? Follow-up of a randomised controlled trial. J Autism Dev Disord. 201422 Dec;42(12):2693-701. doi: 10.1007/s10803-012-1526-8.

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Wenger TL et al., 2016. 22q11.2 duplication syndrome: elevated rate of autism spectrum disorder and need for medical screening. Mol Autism. 7:27. doi: 10.1186/s13229-016-0090-z. eCollection 2016.

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Praise for “Causes”


“With nearly one in fifty US children being diagnosed with autism, The Environmental and Genetic Causes of Autism could not come soon enough. The information in this book needs to be read by all medical students, physicians, and parents. I highly recommend this book.”
—Dr. David Brownstein, MD, medical director, Center for Holistic Medicine

“Dr. Lyons-Weiler is an inspired American scientist. . . . I can say without reservation that this learned person has the ethics of a true teacher, the type idealized from the roots of Western Civilization. He analyzes scientific data for the sake of improving the human condition without monetary influence. . . . His work is encyclopedic.”
—Dr. Edward “Ted” Fogarty, MD, chair, Department of Radiology, University of North Dakota School of Medicine and Health Sciences

“With over one million new cases per year, a current incidence of one in 45–68 children, and a projected incidence of one in two children within two decades, autism is more than an epidemic—it is a national crisis. At this rate, our entire nation will either be autistic or caring for someone who is. While nearly all efforts and public pronouncements are about management and care, very few are exploring cause. We hear from the medical community that autism is a tragic but inevitable outcome of genetic roulette. Dr. Lyons-Weiler, an impeccably credentialed biologist . . . clearly explains the environmental causes of this terrible spectrum of disorders. In so doing, he provides much-needed hope for its prevention and cure. If you are a parent, health professional, or scientist, this is an essential book to read.”
—Michael Gaeta, DAc, MS, CDN, clinician and educator

“This book is a Bible for anyone who wants to understand the deep science behind the autism epidemic in America. Dr. Lyons-Weiler shows us convincingly that autism is not a mysterious disease with no known cause and no known treatment: it is the expected outcome when you expose a child with a certain genetic makeup to multiple neurotoxins simultaneously.”
—Dr. Stephanie Seneff, senior research scientist at the Massachusetts Institute of Technology (MIT)

“[Dr. James Lyons-Weiler’s new book is a call to action] for the pediatric community to ‘awaken from its dogmatic slumber.’ . . . Until our understanding of [autism spectrum disorders] (and their environmental, genetic, and immunological underpinnings) is secure, we must all be willing to evolve as practitioners and scientists and, thusly, light our own candles in the darkness, lest we fall into an abyss.”
—Dr. Anthony Kovatch, MD, pediatrician, Pediatric Alliance

“Lyons-Weiler has done us all an immense service by putting together this well-documented and highly informative overview of autism. Those who are really seeking answers and a way forward will welcome this book. Those whose interests are threatened will not. Indeed, Lyons-Weiler will be able to measure just how much he has stung big pharma by the number of pharma-paid negative reviews in the media, and by the troll attacks, and the denunciations by the CDC. He should wear all these as a badge of [honor] for ultimately the truth will come out. This book will help the truth emerge.”
—Christopher A. Shaw, PhD, author of Neural Dynamics of Neurological Disease



Chapter 1 Background and Concepts


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Ball LK, 2001. An assessment of Thimerosal use in childhood vaccines. Pediatrics 107:1147–54.

Bakos J et al., 2015. Are molecules involved in neuritogenesis and axon guidance related to autism pathogenesis? Neuromolecular Med. 17(3):297-304. doi: 10.1007/s12017-015-8357-7.

Barry, K. 2015. Vaccine Whistleblower: Exposing Autism Research Fraud at the CDC. Skyhorse Publishing, NY.

Bennabi M et al., 2015. Dectin-1 polymorphism: A genetic disease specifier in autism spectrum disorders? PLoS One. 10(9):e0137339. doi: 10.1371/journal.pone.0137339.

Beunders G et al., 2016. A detailed clinical analysis of 13 patients with AUTS2 syndrome further delineates the phenotypic spectrum and underscores the behavioural phenotype. J Med Genet. 53(8):523-32. doi: 10.1136/jmedgenet-2015-103601.

Bernier R et al., 2014. Disruptive CHD8 mutations define a subtype of autism early in development. Cell 158:263–276. doi: 10.1016/j.cell.2014.06.017.

Bhattacharjee S et al., 2013. Selective accumulation of aluminum in cerebral arteries in Alzheimer’s disease (AD). J Inorg Biochem. 126:35-7. doi: 10.1016/j.jinorgbio.2013.05.007.

Bilimoria PM et al., 2015. Microglia function during brain development: New insights from animal models. Brain Res. 1617:7-17. doi: 10.1016/j.brainres.2014.11.032.

Boshes RA et al., 2012. Genetics of the schizophrenias: a model accounting for their persistence and myriad phenotypes. Harv Rev Psychiatry. 20(3):119-29. doi: 10.3109/10673229.2012.694321.

Bowers K, C. Erickson. 2014. Gene-environment interaction and autism spectrum disorder. OA Autism 2(1):3.

Brandler WM et al. 2016. Frequency and complexity of de novo structural mutation in autism. Am J Hum Genet. 98(4):667-79. doi: 10.1016/j.ajhg.2016.02.018.

Braunschweig D et al., 2012. Maternal autoantibodies in autism. Arch Neurol. 69(6):693-9. doi: 10.1001/archneurol.2011.2506.

Breece E et al., 2013. Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain Behav Immun.31:69-75. doi: 10.1016/j.bbi.2012.10.006.

Bresnahan M et al., 2007. Race and risk of schizophrenia in a US birth cohort: another example of health disparity? Int J Epidemiol. 36(4):751-8.

Brown AS 2012. Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol. 72(10):1272-6. doi: 10.1002/dneu.22024.

Buescher AV, 2014. Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatr. 168(8):721-8. doi: 10.1001/jamapediatrics.2014.210.

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Environmental and Genetic Causes of Autism

Environmental and Genetic Causes of Autism

Praise for “Causes”

Chapter 1. Background and Concepts 5

Chapter 2. Symptoms and Diagnosis of Autism 69

Chapter 3. Evidence of Genetic and Epigenetic Risk Components of Autism
and Autism Spectrum Disorder 87

Chapter 4. Speech, Language, and Communication Phenotypes in ASD 116

Chapter 5. Genetic and Environmental Factors That Influence
Social Cognitive Skills in ASD 134

Chapter 6. Cognitive Phenotypes in ASD 153

Chapter 7. Repetitive Motor Behaviors and Seizure Phenotypes 159

Chapter 8. Sensory Phenotypes and Sensory Processing Disorder 165

Chapter 9. Immunological Factors in Autism and ASD 169

Chapter 10. Gastrointestinal and Renal Phenotypes 192

Chapter 11. Neurotoxin-Induced Autoimmune-Mediated
Neurological Damage in Autism 200

Chapter 12. Vaccine-Autism Studies Ignored by the CDC 217

Chapter 13. Concepts of Comorbidity in Autism and Autism Research 230

Chapter 14. Study Designs for Meaningful Future Causal Research
in Autism 241

Chapter 15. Biological Pathways and Networks Views of Autism 253

Chapter 16. Toward a Multidimensional Matrix Risk Model
for Autism 260

Chapter 17. The Logic of Prevention in Autism
and Gene-Informed Treatment 271

Chapter 18. Injecting Objective Association and Causal Inference into
Clinical Trials, Prevention, Diagnosis, and Treatment of ASD 292