Author: envgencauses

Chapter 16. Toward a Multidimensional Matrix Risk Model for Autism

Abraham A, et al., 2008. Minds, persons and space: an fMRI investigation into the relational complexity of higher-order intentionality. Conscious Cogn. 17(2):438-50. doi: 10.1016/j.concog.2008.03.011.

Belgard TG et al., 2014. Population structure confounds autism genetic classifier. Mol Psychiatry. 19(4):405-7. doi: 10.1038/mp.2013.34.

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Gergely, G. and JS Watson. 1999. Contingency perception and the social-feedback model. in: Philippe Rochat, Ed. Early Social Cognition (Hillsdale, NJ: Erlbaum, 1999).

Kontaris et al., 2009. Dissociation of extrastriate body and biological-motion selective areas by manipulation of visual-motor congruency. Neuropsychologia. 47(14): 3118–3124. doi: 10.1016/j.neuropsychologia.2009.07.012.

Milne E et al., 2009. Independent component analysis reveals atypical electroencephalographic activity during visual perception in individuals with autism. Biol Psychiatry. 65(1):22-30. doi: 10.1016/j.biopsych.2008.07.017.

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Nevison CD. 2014. A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors. Environ Health. 13:73. doi: 10.1186/1476-069X-13-73.

Okamoto Y et al., 2014. Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder. Neurosci Res. 87:66-76. doi: 10.1016/j.neures.2014.06.012.

Robinson EB et al., 2014. Response to ‘Predicting the diagnosis of autism spectrum disorder using gene pathway analysis’. Mol Psychiatry19(8):859-61. doi: 10.1038/mp.2013.125.

Skafidas E et al., 2014. Response to Belgard et al. Mol Psychiatry. 19(4):407-9. doi: 10.1038/mp.2013.186.

Skafidas E et al., 2014. Predicting the diagnosis of autism spectrum disorder using gene pathway analysis. Mol Psychiatry. 19(4):504-10. doi: 10.1038/mp.2012.126.

Schroeder JC et al., 2015. Genetic animal models for autism spectrum disorder. Curr Top Behav Neurosci. 2015 Nov 25 pp 1-14.

Talkvik I et al., 2015. Clinical Phenotype of De Novo GNAO1 Mutation. Child Neurology, 2:2 doi: 10.1177/2329048X15583717

Theoharides TC et al., 2013. Focal brain inflammation and autism. J Neuroinflammation. 10:46. doi: 10.1186/1742-2094-10-46.

Uddin M et al., 2014. Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder. Nat Genet. 46(7):742-7. doi: 10.1038/ng.2980.

Veenstra-VanderWeele J, Blakely RD, 2012. Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments. Neuropsychopharmacology. 37(1):196-212. doi: 10.1038/npp.2011.185.

Weiner et al., 2011. Not one extrastriate body area: Using anatomical landmarks, hMT+ and visual field maps to parcellate limb-selective activations in human lateral occipitotemporal cortex. Neuroimage. 56(4): 2183–2199. doi: 10.1016/j.neuroimage.2011.03.041


Chapter 14. Study Designs for Meaningful Future Causal Research in Autism

Barr, K. 2015. Vaccine Whistleblower: Exposing Autism Research Fraud in the CDC. Skyhorse Publishing, New York.

Curtis B, et al., 2015. Examination of the safety of pediatric vaccine schedules in a non-human primate model: assessments of neurodevelopment, learning and social behavior. Environ Health Perspect. 123(6):579-89. doi: 10.1289/ehp.1408257.

Fine PE and RT Chen. 1992. Confounding in studies of adverse reactions to vaccines. Am J Epidemiol. 136(2):121-35.

Gadad BS et al., 2015. Administration of Thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology. Proc Natl Acad Sci U S A. 112(40):12498-503. doi: 10.1073/pnas.1500968112.

Han S et al. 2012. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature. 489(7416):385-90. doi: 10.1038/nature11356. 2015. Gadad et al. 2015 PNAS Journal. Vaccine Papers: An Objective Look at Vaccines Dangers, Oct 27, 2015.

Sebro R and JJ Rogus. 2010. The power of the Transmission Disequilibrium Test in the presence of population stratification. Eur J Hum Genet. 18(9):1032-8. doi: 10.1038/ejhg.2010.57.

SafeMinds, 2016 (accessed 1/5/2016). Vaccines and Autism: What do Epidemiological Studies Really Tell Us?

Verstraeten, T., R. David and F. DeStefano. 2000. Thimerosal VSD Study Phase I. CDC Internal Report Feb 29, 2000 marked “CONFIDENTIAL” and “DO NOT COPY OR RELEASE”. Accessed Jan 6, 2016

Wahlund, S. 1928. Zusammensetzung von Population und Korrelationserscheinung vom Standpunkt der Vererbungslehre aus betrachtet. Hereditas 11:65–106.


Chapter 13. Concepts of Comorbidity in Autism and Autism Research

Abbeduto, L. et al., 2015. Chapter 8. Neurodevelopmental Disorders, The American Psychiatric Publishing Textbook of Psychiatry (6 ed.). Arlington, VA: American Psychiatric Publishing. ISBN 978-1-58562-444-7.

Amiet C, et al., 2013. Epilepsy in simplex autism pedigrees is much lower than the rate in multiplex autism pedigrees. Biol Psychiatry. 74(3):e3-4. doi: 10.1016/j.biopsych.2013.01.037.

Bilder DA, 2016. Brief Report: the prevalence of Neurofibromatosis Type 1 among children with autism spectrum disorder identified by the autism and developmental disabilities monitoring network. J Autism Dev Disord. 2016 Jul 27.

Bird G, R Cook. 2013. Mixed emotions: the contribution of alexithymia to the emotional symptoms of autism. Transl Psychiatry3:e285. doi: 10.1038/tp.2013.61.

Cook R et al. 2013. Alexithymia, not autism, predicts poor recognition of emotional facial expressions. Psychol Sci. 24(5):723-32. doi: 10.1177/0956797612463582.

Crespi, B et al. 2010. Comparative genomics of autism and schizophrenia. PNAS 107:1736-1741.

Frye RE and DA Rossignol. 2016. Identification and treatment of pathophysiological comorbidities of autism spectrum disorder to achieve optimal outcomes. Clin Med Insights Pediatr. 2016 Jun 15;10:43-56. doi: 10.4137/CMPed.S38337. eCollection 2016.

Griffin C et al., 2015. Alexithymia in children with and without autism spectrum disorders. Autism Res. doi: 10.1002/aur.1569.

La Malfa G et al. 2004. Autism and intellectual disability: a study of prevalence on a sample of the Italian population. J Intellect Disabil Res. 48:262–7.

LaFrance Jr WC et al., 2008. Psychiatric comorbidities in epilepsy. Int Rev Neurobiol. 83:347–83.

Iverson JM and RH Wozniak. 2007. Variation in vocal-motor development in infant siblings of children with autism. J Autism Dev Disord. 37(1):158-70.

Silani, G et al.2007. Levels of emotional awareness and autism: An fMRI study. Social Neuroscience 3:97-112.

Tuchman R et al.. 2002. Epilepsy in autism. Lancet Neurol 1: 352–358.

Wang Q et al., 2015. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Hum Genet.134(11-12):1195-209. doi: 10.1007/s00439-015-1596-8.

Zerbo O. 2015. Immune mediated conditions in autism spectrum disorders. Brain Behav Immun. 46:232-6. doi: 10.1016/j.bbi.2015.02.001.

Zerbo O et al. 2016. Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: the early markers for autism study. Transl Psychiatry. 6:e783. doi: 10.1038/tp.2016.46.


Chapter 12. Vaccine-Autism Studies Ignored by the CDC

Agmon-Levin N et al. 2009. Vaccines and autoimmunity. Nat Rev Rheumatol. 5:648–652.

Atkinson et al., 2002. General Recommendations on Immunization Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP)

Blaurock-Busch E et al., 2012. Toxic metals and essential elements in hair and severity of symptoms among children with autism. Maedica 7(1):38-48.

Bradstreet, J. et al.,2003. A case-control study of mercury burden in children with autistic spectrum disorders. J. American Physicians and Surgeons. 8:76-79.

Deavenport-Saman A et al., 2015. Do children with autism overutilize the emergency department? examining visit urgency and subsequent hospital admissions. Matern Child Health J. 2015 Oct 31.

Delong G, 2011. A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population. J Toxicol Environ Health A. 74(14):903-16. doi: 10.1080/15287394.2011.573736.

DeSoto MC. 2008. A reply to Soden et al.: your data shows autistic children have higher levels of heavy metals. Clin Toxicol (Phila). 46(10):1098; author reply 1098. doi: 10.1080/15563650802314368.

Fido A and S Al-Saad, 2005. Toxic trace elements in the hair of children with autism. Autism. 9(3):290-8.

Gallagher CM and MS Goodman. 2010. Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002. J Toxicol Environ Health A. 73(24):1665-77. doi: 10.1080/15287394.2010.519317.

Geier DA and MR Geier. 2007. A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders. J Toxicol Environ Health A. 70(10):837-51.

Hobson D. 1973. Postgrad Med J. 1973. The potential role of immunological adjuvants in influenza vaccines. 49(569):180-84.

Holmes AS et al. 2003. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 22(4):277-85.

Langer-Gould A et al. 2014. Vaccines and the risk of multiple sclerosis and other central nervous system demyelinating diseases. JAMA Neurol. 2014 Dec;71(12):1506-13. doi: 10.1001/jamaneurol.2014.2633.

Li X et al., 2009. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 207(1-2):111-6. doi: 10.1016/j.jneuroim.2008.12.002.

Liu XQ, 2011. Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders. J Am Acad Child Adolesc Psychiatry. 50(7):687-696.e13. doi: 10.1016/j.jaac.2011.05.002.

McDonald K et al.,2008. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J Allergy Clin Immunol. 121(3):626-31. doi: 10.1016/j.jaci.2007.11.034.

Mohamed Fel B et al., 2015. Assessment of hair aluminum, lead and mercury in a sample of autistic Egyptian children: environmental risk factors of heavy metals in autism. Behav Neurol. 2015:545674. doi: 10.1155/2015/545674.

Moise L et al., 2015. T cell epitope redundancy: cross-conservation of the TCR face between pathogens and self and its implications for vaccines and auto-immunity. Expert Rev Vaccines. 2015 Nov 20. DOI:10.1586/14760584.2016.1123098

Molina V and Y Shoenfeld. 2005. Infection, vaccines and other environmental triggers of autoimmunity. Autoimmunity. 38(3):235-45.

Nataf R et al., 2006. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol. 214(2):99-108.

National Academy of Sciences, 2012. Adverse effects of vaccines: evidence and causality. Committee to Review Adverse Effects of Vaccines; Institute of Medicine 978-0-309-21435-3

Orbach, H. 2010. Vaccines and Autoimmune Diseases of the Adult. Discovery Medicine.

Palmer RF et al., 2006. Environmental mercury release, special education rates and autism disorder: an ecological study of Texas. Health Place. 12(2):203-9.

Poling JS, et al., 2006. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol. 21(2):170-2.

Rinaldi M et al., 2014. Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines. Lupus. 2014 May;23(6):554-67. doi: 10.1177/0961203313499959.

Rosenhall U et al., 1999. Autism and hearing loss. J Autism Dev Disord. 29(5):349-57.

Seneff S et al., 2012. Empirical data confirm autism symptoms related to aluminum and acetaminophen exposure. Entropy 14(11), 2227-2253; doi:10.3390/e14112227.

Sharpe MA, et al., 2013. B-Lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal.  J Toxicol. 2013:801517. doi: 10.1155/2013/801517.

Singh VK et al., 1998. Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol. 89(1):105-8.

Soden SE. 2007. 24-hour provoked urine excretion test for heavy metals in children with autism and typically developing controls, a pilot study. Clin Toxicol (Phila). 45(5):476-81.

Thomas P et al., 2012. The association of autism diagnosis with socioeconomic status. Autism. 2012 16(2):201-13. doi: 10.1177/1362361311413397.

Wahlund, S. 1928. Zusammensetzung von Population und Korrelationserscheinung vom Standpunkt der Vererbungslehre aus betrachtet. Hereditas 11:65–106.

Vargas DL et al., 2005. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 57(1):67-81.

Yasuda H and T Tsutsui. 2013. Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs). Int J Environ Res Public Health. 10(11):6027-43. doi: 10.3390/ijerph10116027.

Yasuda H et al., 2013. Estimation of autistic children by metallomics analysis. Sci Rep. 3:1199. doi: 10.1038/srep01199.

Yirkud, YV, et al. 2009. Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. Am J Med Genet B Neuropsychiatr Genet. 150B: 328–334.

Young HA et al., 2008. Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the Vaccine Safety Datalink. J Neurol Sci. 271(1-2):110-8. doi: 10.1016/j.jns.2008.04.002.